Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.

ABSTRACT: It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, using human intestinal epithelial cells we could show that although both type I and type III IFNs confer an antiviral state to the cells, they do so with distinct kinetics. Type I IFN signaling is characterized by an acute strong induction of interferon stimulated genes (ISGs) and confers fast antiviral protection. On the contrary, the slow acting type III IFN mediated antiviral protection is characterized by a weaker induction of ISGs in a delayed manner compared to type I IFN. Moreover, while transcript profiling revealed that both IFNs induced a similar s

SUBMITTER: Pervolaraki K 

PROVIDER: S-EPMC6287881 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature