VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress.

ABSTRACT: This review presents current knowledge related to VDAC1 as a multi-functional mitochondrial protein acting on both sides of the coin, regulating cell life and death, and highlighting these functions in relation to disease. It is now recognized that VDAC1 does not only play a crucial role in regulating the metabolic and energetic functions of mitochondria. The location of VDAC1 at the outer mitochondrial membrane (OMM) allows the control of metabolic cross-talk between mitochondria and the rest of the cell and also enables its interaction with proteins involved in metabolic and survival pathways. Along with regulating cellular energy production and metabolism, VDAC1 is also involved in the process of mitochondria-mediated apoptosis by mediating the release of apoptotic proteins and interact

SUBMITTER: Shoshan-Barmatz V 

PROVIDER: S-EPMC6287957 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature