Antithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts.

ABSTRACT: Salvia deserta Schang (SDS) belongs to the same family as Salvia miltiorrhiza bunge, one of the antithrombotic Chinese herbal medicines. In our study, EtOAc root extracts were analyzed for their effects on adenosine diphosphate (ADP)-induced platelet aggregation in rabbits and FeCl₃-induced rat common carotid artery thrombosis as well as on rat blood plasma concentrations of thromboxane B2 (TXB₂), 6-keto-prostaglandin F1 alpha (6-keto-PGF_1α), antithrombin-III (AT-III), protein C (PC), plasminogen (PLG), plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF) and tissue-type plasminogen activator (t-PA). EtOAc extracts from SDS roots had significant inhibitory effects on ADP-induced maximum platelet aggregation rate (10.2 ± 2.6 vs control 35.7 ±

SUBMITTER: Kasimu R 

PROVIDER: S-EPMC6288089 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature