Exploring the transcriptome of hormone-naive multifocal prostate cancer and matched lymph node metastases.

ABSTRACT:

Background

The current inability to predict whether a primary prostate cancer (PC) will progress to metastatic disease leads to overtreatment of indolent PCs as well as undertreatment of aggressive PCs. Here, we explored the transcriptional changes associated with metastatic progression of multifocal hormone-naive PC.

Methods

Using total RNA-sequencing, we analysed laser micro-dissected primary PC foci (n = 23), adjacent normal prostate tissue samples (n = 23) and lymph node metastases (n = 9) from ten hormone-naive PC patients. Genes important for PC progression were identified using differential gene expression and clustering analysis. From these, two multi-gene-based expression signatures (models) were developed, and their prognostic potential was evaluated using Cox-regr

SUBMITTER: Schmidt L 

PROVIDER: S-EPMC6288156 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature