Toxoplasma gondii Genotype Determines Tim-3 Expression Levels in Splenic and Circulatory T Cells in Mice.

ABSTRACT: Toxoplasma gondii is an obligatory intracellular parasite that causes a common infection in many warm-blooded animals. During infection, the host's immune system plays an important role in confining the dissemination of the parasites in the hosts. T cell immunoglobulin- and mucin domain-containing molecule 3 (Tim-3) has been characterized as an important regulator in cell-mediated immune responses in various infections. Here, we compared Tim-3 expression on splenic and circulatory T, B cells and a few cytokines in the sera of mice infected with the more virulent type I (RH) vs. the low virulent type II (ME49) strain. Tim-3 expression on the splenic and circulatory T cells of mice infected with T. gondii (RH strain) was higher than that in mice infected with T. gondii (ME49 strain). T. gond

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6288189 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature