An Investigation Into Physical Frailty as a Link Between the Gut Microbiome and Cognitive Health.

ABSTRACT: The preservation of cognitive abilities with aging is a priority both for individuals and nations given the aging populations of many countries. Recently the gut microbiome has been identified as a new territory to explore in relation to cognition. Experiments using rodents have identified a link between the gut microbiome and cognitive function, particularly that low microbial diversity leads to poor cognition function. Similar studies in humans could identify novel targets to encourage healthy cognition in an aging population. Here, we investigate the association of gut microbiota and cognitive function in a human cohort considering the influence of physical frailty. We analyzed 16S rRNA gene sequence data, derived from fecal samples obtained from 1,551 individuals over the age of 40. Co

SUBMITTER: Verdi S 

PROVIDER: S-EPMC6288358 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature