De novo recruitment of Polycomb-group proteins in Drosophila embryos.

ABSTRACT: Polycomb-group (PcG)-mediated transcriptional repression of target genes can be delineated into two phases. First, following initial repression of target genes by gene-specific transcription factors, PcG proteins recognize the repressed state and assume control of the genes' repression. Second, once the silenced state is established, PcG proteins may maintain repression through an indefinite number of cell cycles. Little is understood about how PcG proteins initially recognize the repressed state of target genes and the steps leading to de novo establishment of PcG-mediated repression. We describe a genetic system in which a Drosophila PcG target gene, giant (gt), is ubiquitously repressed during early embryogenesis by a maternally expressed transcription factor

SUBMITTER: Alhaj Abed J 

PROVIDER: S-EPMC6288389 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature