Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies.

ABSTRACT: Learning the transmission history of alleles through a family or population plays an important role in evolutionary, demographic, and medical genetic studies. Most classical models of population genetics have attempted to do so under the assumption that the genealogy of a population is unavailable and that its idiosyncrasies can be described by a small number of parameters describing population size and mate choice dynamics. Large genetic samples have increased sensitivity to such modeling assumptions, and large-scale genealogical datasets become a useful tool to investigate realistic genealogies. However, analyses in such large datasets are often intractable using conventional methods. We present an efficient method to infer transmission paths of rare alleles through population-scale gene

SUBMITTER: Nelson D 

PROVIDER: S-EPMC6288464 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature