Learned Spatial Schemas and Prospective Hippocampal Activity Support Navigation After One-Shot Learning.

ABSTRACT: Prior knowledge structures (or schemas) confer multiple behavioral benefits. First, when we encounter information that fits with prior knowledge structures, this information is generally better learned and remembered. Second, prior knowledge can support prospective planning. In humans, memory enhancements related to prior knowledge have been suggested to be supported, in part, by computations in prefrontal and medial temporal lobe (MTL) cortex. Moreover, animal studies further implicate a role for the hippocampus in schema-based facilitation and in the emergence of prospective planning signals following new learning. To date, convergence across the schema-enhanced learning and memory literature may be constrained by the predominant use of hippocampally dependent spatial navigation paradigm

SUBMITTER: van Kesteren MTR 

PROVIDER: S-EPMC6288548 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature