Structure, clustering and functional insights of repeats configurations in the upstream promoter region of the human coding genes.

ABSTRACT:

Background

Repetitive DNA sequences (Repeats) are significant regions in the human genome that have a specific genomic distribution, structure, and several binding sites for genome architecture and function. In consequence, the possible configurations of Repeats in specific and dynamic regions like the gene promoters could define footprints for molecular mechanisms, pathways, and cell function beyond their density in the genome. Here we explored the distribution of Repeats in the upstream promoter region of the human coding genes with the aim to identify specific configurations, clusters and functional meaning of those elements. Our method includes structural descriptions, hierarchical clustering, pathway association, and functional enrichment analysis.

Results

We report her

SUBMITTER: Tobar-Tosse F 

PROVIDER: S-EPMC6288848 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature