Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling.

ABSTRACT:

Background

Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information.

Results

We built an integrated dataset with 1273 human colorectal samples, which provides a homogeneous robust framework to analyse genome-wide expression and survival data. Using this dataset we identified two sets of genes that are candidate prognostic markers for CRC in stages II

SUBMITTER: Martinez-Romero J 

PROVIDER: S-EPMC6288855 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature