A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism.

ABSTRACT:

Background

Phytophthora infestans is a plant pathogen that causes an important plant disease known as late blight in potato plants (Solanum tuberosum) and several other solanaceous hosts. This disease is the main factor affecting potato crop production worldwide. In spite of the importance of the disease, the molecular mechanisms underlying the compatibility between the pathogen and its hosts are still unknown.

Results

To explain the metabolic response of late blight, specifically photosynthesis inhibition in infected plants, we reconstructed a genome-scale metabolic network of the S. tuberosum leaf, PstM1. This metabolic network simulates the effect of this disease in the leaf metabolism. PstM1 accounts for 2751 genes, 1113 metabolic functions, 1773 gene-protein-reaction as

SUBMITTER: Botero K 

PROVIDER: S-EPMC6288859 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature