SKA1 overexpression is associated with poor prognosis in hepatocellular carcinoma.

ABSTRACT:

Background

SKA1, an important mitosis protein, has been indicated in the initiation and progression of several malignancies. However, its clinical significance in hepatocellular carcinoma (HCC) remain to be elucidated.

Methods

mRNA expression of SKA1 was examined in 126 HCC and paired non-neoplastic tissues using real-time PCR and validated in The Cancer Genome Atlas (TCGA) database. SKA1 protein expression was detected using immunohistochemistry in the 126 HCC tissues and its associations with clinicopathological parameters and prognosis were analyzed. Hierarchical cluster analysis and gene set enrichment analysis (GSEA) were performed in selected Gene Expression Omnibus data sets.

Results

SKA1 mRNA expression was significantly elevated in HCC tissues from both local

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6288885 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature