Porcine circovirus type 2 ORF3 protein induces apoptosis in melanoma cells.

ABSTRACT:

Background

The current treatment of malignant melanoma is limited by the lack of effective therapeutic approaches, and alternative treatments are needed. Proliferative diseases such as melanoma and other cancers may be treatable by virally-encoded apoptotic proteins that are targeted to rapidly multiplying cells. Caspase-dependent apoptosis, that is frequently used in chemotherapy, can boost the cell proliferation that caspase-independent cell death does not.

Methods

In the current study, the porcine circovirus type 2 (PCV2), proapoptotic protein ORF3 was expressed in mouse and human cancer cell lines, and its apoptotic activity was assessed.

Results

Quantitative assessment of the apoptotic cells by flow cytometry showed that apoptotic cell death was significantly inc

SUBMITTER: Teras M 

PROVIDER: S-EPMC6288936 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature