Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.

ABSTRACT:

Background

Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.

Methods

From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Participants were randomly assigned to receive 100 mg of enteric-coated aspirin or placebo. The primary end point was a composite of death, dementia, or persistent physical disability; results for this end point are reported in another article in the Journal.

SUBMITTER: McNeil JJ 

PROVIDER: S-EPMC6289056 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature