Transferrin receptor-targeted HMSN for sorafenib delivery in refractory differentiated thyroid cancer therapy.

ABSTRACT:

Background

Thyroid cancer becomes the most common endocrine cancer with the greatest growing incidence in this decade. Sorafenib is a multikinase inhibitor for the treatment of progressive radioactive iodine-refractory differentiated thyroid cancer (DTC), while the off-target toxicity effect is usually inconvenient for patients taking.

Methods

In this study, hollow mesoporous silica nanoparticles (HMSNs) with transferrin modification (Tf-HMSNs) were loaded with sorafenib (sora@Tf-HMSNs) to help targeted delivery of sorafenib. Due to the biocompatible Tf shell, Tf-HMSNs exhibited excellent bio-compatibility and increased intracellular accumulation, which improved the targeting capability to cancer cells in vitro and in vivo.

Results

Sora@Tf-HMSNs treatment exhibited th

SUBMITTER: Ke Y 

PROVIDER: S-EPMC6289230 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature