Multiple treatment comparison in narcolepsy: a network meta-analysis.

ABSTRACT:

Study objectives

Randomized controlled trials (RCTs) that compared the safety and efficacy of medical treatments for narcolepsy were analyzed using network meta-analysis.

Methods

The RCTs in narcolepsy were searched. Network meta-analysis compared efficacy and safety of multiple treatments, multi-arm studies, and multi-criteria treatment decisions, based on a random model that assumed heterogeneity between studies, with corrections for multi-arm studies.

Results

Fourteen RCTs, three drug treatments, and six doses were identified: sodium oxybate (6 and 9 g/d), modafinil (between 200 and 400 mg/d), and pitolisant (up to 20 and up to 40 mg/d). Significant heterogeneity (>50%) between studies was found in 12/14 studies for almost all endpoints, but between-design consiste

SUBMITTER: Lehert P 

PROVIDER: S-EPMC6289237 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature