Precision identification of diverse bloodstream pathogens in the gut microbiome.

ABSTRACT: A comprehensive evaluation of every patient with a bloodstream infection includes an attempt to identify the infectious source. Pathogens can originate from various places, such as the gut microbiota, skin and the external environment. Identifying the definitive origin of an infection would enable precise interventions focused on management of the source^1,2. Unfortunately, hospital infection control practices are often informed by assumptions about the source of various specific pathogens; if these assumptions are incorrect, they lead to interventions that do not decrease pathogen exposure³. Here, we develop and apply a streamlined bioinformatic tool, named StrainSifter, to match bloodstream pathogens precisely to a candidate source. We then leverage this approach to

SUBMITTER: Tamburini FB 

PROVIDER: S-EPMC6289251 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature