Graft-versus-Host Disease of the Gut: A Histologic Activity Grading System and Validation.

ABSTRACT: The pathologic interpretation of gut biopsies in hematopoietic cell transplant recipients to assess graft-versus-host disease (GVHD) is well accepted and supplements clinical and endoscopic findings. However, the histologic activity grading of GVHD is controversial, with attempts to predict prognosis or response to treatment largely unsuccessful. GVHD is being diagnosed earlier in its course, raising the possibility that the pathologic grading system can be profitably modified. We developed a histologic activity grading system designed to replace the commonly used modified Lerner grading systems. Our system stratifies the low-level Lerner grade I category into 4 activity grade categories, based on the average frequency of apoptotic cells. The results are expressed as ordinal categories: GV

SUBMITTER: Myerson D 

PROVIDER: S-EPMC6289287 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature