Amperometric Glucose Sensing at Nanomolar Level Using MOF-Encapsulated TiO2 Platform.

ABSTRACT: A new synthetic approach is established where both TiO2 nanoparticles and glucose oxidase (GO x ) are together encapsulated into the cavity of ZIF-8 metal-organic framework (MOF) to fabricate a mediator-free glucose sensor in aqueous media. ZIF-8 possesses high stability both physically and chemically. Moreover, its large surface area and tunable cavity size are supportive to encapsulate both nanoparticles (TiO2) and enzymes (GO x ). The as-synthesized nanocomposite is methodically characterized by various advanced analytical techniques, which suggests that TiO2 is uniformly distributed within the cavity of ZIF-8 MOF. High surface area and double-layer capacitance of nanostructured TiO2 jointly enhance the catalytic biosensor activity. The as-synthesized nanocomposite exhibits commendable

SUBMITTER: Paul A 

PROVIDER: S-EPMC6289493 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature