Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome.

ABSTRACT: We reconstructed, from a whole CNS EM volume, the synaptic map of input and output neurons that underlie food intake behavior of Drosophila larvae. Input neurons originate from enteric, pharyngeal and external sensory organs and converge onto seven distinct sensory synaptic compartments within the CNS. Output neurons consist of feeding motor, serotonergic modulatory and neuroendocrine neurons. Monosynaptic connections from a set of sensory synaptic compartments cover the motor, modulatory and neuroendocrine targets in overlapping domains. Polysynaptic routes are superimposed on top of monosynaptic connections, resulting in divergent sensory paths that converge on common outputs. A completely different set of sensory compartments is connected to the mushroom body calyx. The mushroom

SUBMITTER: Miroschnikow A 

PROVIDER: S-EPMC6289573 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature