Characteristics of interactions at protein segments without non-local intramolecular contacts in the Protein Data Bank.

ABSTRACT: The principle of three-dimensional protein structure formation is a long-standing conundrum in structural biology. A globular domain of a soluble protein is formed by a network of atomic contacts among amino acid residues, but regions without intramolecular non-local contacts are often observed in the protein structure, especially in loop, linker, and peripheral segments with secondary structures. Although these regions can play key roles for protein function as interfaces for intermolecular interactions, their nature remains unclear. Here, we termed protein segments without non-local contacts as floating segments and sought them in tens of thousands of entries in the Protein Data Bank. As a result, we found that 0.72% of residues are in floating segments. Regarding secondary structural el

SUBMITTER: Kasahara K 

PROVIDER: S-EPMC6289587 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature