Improved sensitivity and temporal resolution in perfusion FMRI using velocity selective inversion ASL.

ABSTRACT:

Purpose

This work aims to investigate the utility of velocity selective inversion pulses for perfusion weighted functional MRI.

Methods

Tracer kinetic properties of velocity selective inversion (VSI) pulses as an input function for an arterial spin labeling (ASL) experiment were characterized in a group of healthy participants. Numerical simulations were conducted to search for a robust set of timing parameters for FMRI time series acquisition with maximal signal to noise ratio efficiency. The performance of three VSI pulse sequences with different timing parameters was compared with a pseudocontinuous ASL sequence in a simple FMRI experiment conducted on healthy participants.

Results

The fit to the tracer kinetic model yielded arterial CBV of 1.24% ± 0.52% and 0.45 ±

SUBMITTER: Hernandez-Garcia L 

PROVIDER: S-EPMC6289627 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature