Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?

ABSTRACT: The role of sleep in brain physiology is poorly understood. Recently rodent studies have shown that the glymphatic system clears waste products from brain more efficiently during sleep compared to wakefulness due to the expansion of the interstitial fluid space facilitating entry of cerebrospinal fluid (CSF) into the brain. Here, we studied water diffusivity in the brain during sleep and awake conditions, hypothesizing that an increase in water diffusivity during sleep would occur concomitantly with an expansion of CSF volume - an effect that we predicted based on preclinical findings would be most prominent in cerebellum. We used MRI to measure slow and fast components of the apparent diffusion coefficient (ADC) of water in the brain in 50 healthy participants, in 30 of whom we compared a

SUBMITTER: Demiral SB 

PROVIDER: S-EPMC6289767 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature