Tissue Flow Induces Cell Shape Changes During Organogenesis.

ABSTRACT: In embryonic development, cell shape changes are essential for building functional organs, but in many cases, the mechanisms that precisely regulate these changes remain unknown. We propose that fluid-like drag forces generated by the motion of an organ through surrounding tissue could generate changes to its structure that are important for its function. To test this hypothesis, we study the zebrafish left-right organizer, Kupffer's vesicle (KV), using experiments and mathematical modeling. During development, monociliated cells that comprise KV undergo region-specific shape changes along the anterior-posterior axis that are critical for KV function: anterior cells become long and thin, whereas posterior cells become short and squat. Here, we develop a mathematical vertex-like model for c

SUBMITTER: Erdemci-Tandogan G 

PROVIDER: S-EPMC6289824 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature