Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates.

ABSTRACT: Social relationships are a key determinant of social behaviour, and disruption of social behaviour is a major symptom of several psychiatric disorders. However, few studies have analysed social relationships among multiple individuals in a group or how social relationships within a group influence the behaviour of members with impaired socialisation. Here, we developed a video-analysis-based system, the Multiple-Animal Positioning System (MAPS), to automatically and separately analyse the social behaviour of multiple individuals in group housing. Using MAPS, we show that social isolation of male mice during adolescence leads to impaired social proximity in adulthood. The phenotype of these socially isolated mice was partially rescued by cohabitation with group-housed (socially-reared) mice

SUBMITTER: Endo N 

PROVIDER: S-EPMC6290015 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature