The Influence of Acanthamoeba-Legionella Interaction in the Virulence of Two Different Legionella Species.

ABSTRACT: The genus Legionella comprises more than 60 species, and about half are associated with infection. Legionella pneumophila is the most commonly associated with these infections and by far the most studied, but L. non-pneumophila species, such as L. feeleii, L. anisa, etc., may also present clinical importance. Free-living amoebae are their preferred environmental host, where these bacteria not only survive but also succeed in multiplying, and this relationship can lead to an increase in bacterial virulence. The goal of this study was to evaluate the alterations of Legionella pathogenicity due to its interaction with Acanthamoeba. For this, the expression of protein effectors SdhA, LegK2, and SidK were evaluated in L. pneumophila and L. feeleii, before and after infecting Acanthamoeba. Addit

SUBMITTER: Gomes TS 

PROVIDER: S-EPMC6290054 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature