P53 regulates CD46 expression and measles virus infection in myeloma cells.

ABSTRACT: In this study, we assessed the sensitivity of myeloma cells to the oncolytic measles virus (MV) in relation to p53 using 37 cell lines and 23 primary samples. We showed that infection and cell death were correlated with CD46 expression, which was associated with TP53 status; TP53 ^abn cell lines highly expressed CD46 and were preferentially infected by MV when compared with the TP53 ^wt cell lines (P = .046 and P = .045, respectively). Infection of myeloma cells was fully dependent on CD46 expression in both cell lines and primary cells. In the TP53 ^wt cell lines, but not the TP53 ^abn cell lines, activation of the p53 pathway with nutlin3a inhibited both CD46 expression and MV in

SUBMITTER: Lok A 

PROVIDER: S-EPMC6290095 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature