Robust adaptive immune response against Babesia microti infection marked by low parasitemia in a murine model of sickle cell disease.

ABSTRACT: The intraerythrocytic parasite Babesia microti is the number 1 cause of transfusion-transmitted infection and can induce serious, often life-threatening complications in immunocompromised individuals including transfusion-dependent patients with sickle cell disease (SCD). Despite the existence of strong long-lasting immunological protection against a second infection in mouse models, little is known about the cell types or the kinetics of protective adaptive immunity mounted following Babesia infection, especially in infection-prone SCD that are thought to have an impaired immune system. Here, we show, using a mouse B microti infection model, that infected wild-type (WT) mice mount a very strong adaptive immune response, characterized by (1) coordinated induction of a

SUBMITTER: Yi W 

PROVIDER: S-EPMC6290097 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature