Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins.

ABSTRACT: Most excitatory neurotransmission in the mammalian brain is mediated by a family of plasma membrane-bound signaling proteins called ionotropic glutamate receptors (iGluRs). iGluRs assemble at central synapses as tetramers, forming a central ion-channel pore whose primary function is to rapidly transport Na⁺ and Ca²⁺ in response to binding the neurotransmitter l-glutamic acid. The pore of iGluRs is also accessible to bulkier cytoplasmic cations, such as the polyamines spermine, spermidine, and putrescine, which are drawn into the permeation pathway, but get stuck and block the movement of other ions. The degree of this polyamine-mediated channel block is highly regulated by processes that control the free cytoplasmic polyamine concentration, the membrane potential, or

SUBMITTER: Bowie D 

PROVIDER: S-EPMC6290150 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature