Antimicrobial Chemicals Associate with Microbial Function and Antibiotic Resistance Indoors.

ABSTRACT: Humans purposefully and inadvertently introduce antimicrobial chemicals into buildings, resulting in widespread compounds, including triclosan, triclocarban, and parabens, in indoor dust. Meanwhile, drug-resistant infections continue to increase, raising concerns that buildings function as reservoirs of, or even select for, resistant microorganisms. Support for these hypotheses is limited largely since data describing relationships between antimicrobials and indoor microbial communities are scant. We combined liquid chromatography-isotope dilution tandem mass spectrometry with metagenomic shotgun sequencing of dust collected from athletic facilities to characterize relationships between indoor antimicrobial chemicals and microbial communities. Elevated levels of triclosan and triclocarban,

SUBMITTER: Fahimipour AK 

PROVIDER: S-EPMC6290264 | biostudies-literature | 2018 Nov-Dec

REPOSITORIES: biostudies-literature