Birth Anomalies in Monozygotic and Dizygotic Twins: Results From the California Twin Registry.

ABSTRACT:

Background

Inherited factors and maternal behaviors are thought to play an important role in the etiology of several congenital malformations. Twin studies can offer additional evidence regarding the contribution of genetic and lifestyle factors to common birth anomalies, but few large-scale studies have been reported.

Methods

We included data from twins (20,803 pairs) from the population-based California Twin Program. We compared concordance in monozygotic (MZ) to dizygotic (DZ) twins for the following birth anomalies: clubfoot, oral cleft, spina bifida, muscular dystrophy, deafness, cerebral palsy, strabismus, and congenital heart defects. Each birth anomaly was also examined for the associations with birth characteristics (birthweight and birth order) and parental exposur

SUBMITTER: Yu Y 

PROVIDER: S-EPMC6290277 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature