The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.

ABSTRACT:

Background

Genetic polymorphisms can explain some of the population- and individual-based variations in nutritional status biomarkers.

Objective

We sought to screen the entire human genome for common genetic polymorphisms that influence folate-status biomarkers in healthy individuals.

Design

We carried out candidate gene analyses and genome-wide association scans in 2232 young, healthy Irish subjects to evaluate which common genetic polymorphisms influence red blood cell folate, serum folate, and plasma total homocysteine.

Results

The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate

SUBMITTER: Shane B 

PROVIDER: S-EPMC6290363 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature