Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.

ABSTRACT: Background and Aims: Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. A critical brain region is the hippocampus (HC), where there is a striking intersection between high concentrations of cannabinoid 1 (CB1) receptors and age-related pathology. Design: We investigated whether older adults (average age=66.6+7.2 years old) with a history of early life CB use show morphological differences in hippocampal subregi

SUBMITTER: Burggren AC 

PROVIDER: S-EPMC6290479 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature