Uncoiling CNLs: Structure/Function Approaches to Understanding CC Domain Function in Plant NLRs.

ABSTRACT: Plant nucleotide-binding leucine-rich repeat receptors (NLRs) are intracellular pathogen receptors whose N-terminal domains are integral to signal transduction after perception of a pathogen-derived effector protein. The two major plant NLR classes are defined by the presence of either a Toll/interleukin-1 receptor (TIR) or a coiled-coil (CC) domain at their N-terminus (TNLs and CNLs). Our knowledge of how CC domains function in plant CNLs lags behind that of how TIR domains function in plant TNLs. CNLs are the most abundant class of NLRs in monocotyledonous plants, and further research is required to understand the molecular mechanisms of how these domains contribute to disease resistance in cereal crops. Previous studies of CC domains have revealed functional diversity, making categoriza

SUBMITTER: Bentham AR 

PROVIDER: S-EPMC6290485 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature