BASILIScan: a tool for high-throughput analysis of intrinsic disorder patterns in homologous proteins.

ABSTRACT:

Background

Intrinsic structural disorder is a common property of many proteins, especially in eukaryotic and virus proteomes. The tendency of some proteins or protein regions to exist in a disordered state usually precludes their structural characterisation and renders them especially difficult for experimental handling after recombinant expression.

Results

A new intuitive, publicly-available computational resource, called BASILIScan, is presented here. It provides a BLAST-based search for close homologues of the protein of interest, integrated with a simultaneous prediction of intrinsic disorder together with a robust data viewer and interpreter. This allows for a quick, high-throughput screening, scoring and selection of closely-related yet highly structured homologues of

SUBMITTER: Barski M 

PROVIDER: S-EPMC6290515 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature