Expression of Rift Valley fever virus N-protein in Nicotiana benthamiana for use as a diagnostic antigen.

ABSTRACT:

Background

Rift Valley fever virus (RVFV), the causative agent of Rift Valley fever, is an enveloped single-stranded negative-sense RNA virus in the genus Phlebovirus, family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing abortion storms in pregnant ruminants, high neonatal mortality in animals, and morbidity and occasional fatalities in humans. The disease is endemic in parts of Africa and the Arabian Peninsula, but is described as emerging due to the wide range of mosquitoes that could spread the disease into non-endemic regions. There are different tests for determining whether animals are infected with or have been exposed to RVFV. The most common serological test is antibody ELISA, which detects host immunoglobulins M or G pr

SUBMITTER: Mbewana S 

PROVIDER: S-EPMC6290525 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature