A heterogeneous label propagation approach to explore the potential associations between miRNA and disease.

ABSTRACT:

Background

Research on microRNAs (miRNAs) has attracted increasingly worldwide attention over recent years as growing experimental results have made clear that miRNA correlates with masses of critical biological processes and the occurrence, development, and diagnosis of human complex diseases. Nonetheless, the known miRNA-disease associations are still insufficient considering plenty of human miRNAs discovered now. Therefore, there is an urgent need for effective computational model predicting novel miRNA-disease association prediction to save time and money for follow-up biological experiments.

Methods

In this study, considering the insufficiency of the previous computational methods, we proposed the model named heterogeneous label propagation for MiRNA-disease association

SUBMITTER: Chen X 

PROVIDER: S-EPMC6290528 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature