Nimbolide B and nimbic acid B, phytotoxic substances in neem leaves with allelopathic activity.

ABSTRACT: Neem (Azadirachta indica) has been widely used as a traditional medicine and several bioactive compounds have been isolated from this species, but to date no potent allelopathic active substance has been reported. Therefore, we investigated possible allelopathic property and phytotoxic substances with allelopathic activity in neem. An aqueous methanol extract of neem leaves inhibited the growth of roots and shoots of cress, lettuce, alfalfa, timothy, crabgrass, ryegrass, barnyard grass and jungle rice. The extracts were then purified by several chromatographic runs while monitoring the inhibitory activity and two phytotoxic substances were isolated. The chemical structures of the two substances were determined by spectral data to correspond to novel compounds, nimbolide B (1) and nimbic ac

SUBMITTER: Kato-Noguchi H 

PROVIDER: S-EPMC6290558 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature