Antipsychotics, Metabolic Adverse Effects, and Cognitive Function in Schizophrenia.

ABSTRACT: Cognitive impairment is a core symptom domain of schizophrenia. The effect of antipsychotics, the cornerstone of treatment in schizophrenia, on this domain is not fully clear. There is some evidence suggesting that antipsychotics may partially improve cognitive function, and that this improvement may vary depending on the specific cognitive domain. However, this research is confounded by various factors, such as age, duration/stage of illness, medication adherence, and extrapyramidal side effects that complicate the relationship between antipsychotics and cognitive improvement. Furthermore, antipsychotics-particularly the second generation, or "atypical" antipsychotics-can induce serious metabolic side effects, such as obesity, dyslipidemia and type 2 diabetes, illnesses which themselves h

SUBMITTER: MacKenzie NE 

PROVIDER: S-EPMC6290646 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature