Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.

ABSTRACT:

Aims/hypothesis

Inflammation is associated with increased body mass and purportedly with increased size of adipose cells. We sought to determine whether increased size of adipose cells is associated with localised inflammation in weight-stable, moderately obese humans.

Methods

We recruited 49 healthy, moderately obese individuals for quantification of insulin resistance (modified insulin suppression test) and subcutaneous abdominal adipose tissue biopsy. Cell size distribution was analysed with a multisizer device and inflammatory gene expression with real-time PCR. Correlations between inflammatory gene expression and cell size variables, with adjustment for sex and insulin resistance, were calculated.

Results

Adipose cells were bimodally distributed, with 47% in a '

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC6290757 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature