Increased expression of EZH2 indicates aggressive potential of urothelial carcinoma of the bladder in a Chinese population.

ABSTRACT: Here, we attempt to better define the long-term outcomes of radical cystectomy (RC) for urothelial carcinoma (UC) in a Chinese population and to investigate the relationship between EZH2 protein expression levels and the clinicopathological parameters and outcomes in patients with UC. We detected the relative EZH2 protein expression levels by immunohistochemistry in tumour specimens from a cohort of 189 Chinese UC patients. In patients who underwent RC, the 5-year cancer-specific survival (CSS) and overall survival (OS) were 69% and 61% respectively. EZH2 expression was increased in UC compared with normal urothelium. The expression levels of EZH2 were elevated in parallel with tumour stage (p = 0.001) and tumour grade (p = 0.001) and were increased in cases with lymph node metastasis comp

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6290761 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature