The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description.

ABSTRACT: Although the incidence of dementia increases exponentially with age, some individuals reach more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study ( www.100plus.nl ). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenarians are followed annually until death. PET-MRI scans and feces donation are optional. Almost 30% of the centenarians agreed to post-mortem brain donation. To date (September 2018), 332 centenaria

SUBMITTER: Holstege H 

PROVIDER: S-EPMC6290855 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature