Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers.

ABSTRACT:

Background

Complex clusters of rearrangements are a challenge in interpretation of cancer genomes. Some clusters of rearrangements demarcate clear amplifications of driver oncogenes but others are less well understood. A detailed analysis of rearrangements within these complex clusters could reveal new insights into selection and underlying mutational mechanisms.

Patients and methods

Here, we systematically investigate rearrangements that are densely clustered in individual tumours in a cohort of 560 breast cancers. Applying an agnostic approach, we identify 21 hotspots where clustered rearrangements recur across cancers.

Results

Some hotspots coincide with known oncogene loci including CCND1, ERBB2, ZNF217, chr8:ZNF703/FGFR1, IGF1R, and MYC. Others contain cancer gen

SUBMITTER: Glodzik D 

PROVIDER: S-EPMC6290883 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature