Transcriptomic Landscape of Treatment-Naive Ulcerative Colitis.

ABSTRACT:

Background and aims

Ulcerative colitis [UC] is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease [IBD]. This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared with control patients by using next-generation technology, RNA-Seq.

Methods

Mucosal biopsies from treatment-naïve UC patients [n = 14], and healthy controls [n = 16] underwent RNA-Seq. Principal component analysis [PCA], cell deconvolution methods, and diverse statistical methods were applied to obtain and characterise a dataset of significantly differentially expressed genes [DEGs].

Results

Analyses revealed 1480

SUBMITTER: Taman H 

PROVIDER: S-EPMC6290885 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature