Dataset Information

Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.

ABSTRACT:

Rationale

Epidemiologic studies have demonstrated that exposure to particulate matter ambient pollution has adverse effects on lung health, exacerbated by cigarette smoking. Particulate matter less than or equal to 2.5 μm in aerodynamic diameter (PM_2.5) is among the most harmful urban pollutants and is closely linked to respiratory disease.

Objectives

Based on the knowledge that the small airway epithelium (SAE) plays a central role in the pathogenesis of smoking-related lung disease, we hypothesized that elevated PM_2.5 levels are associated with dysregulation of SAE gene expression, which may contribute to the development of respiratory disease.