External validation of cerebral aneurysm rupture probability model with data from two patient cohorts.

ABSTRACT:

Background

For a treatment decision of unruptured cerebral aneurysms, physicians and patients need to weigh the risk of treatment against the risk of hemorrhagic stroke caused by aneurysm rupture. The aim of this study was to externally evaluate a recently developed statistical aneurysm rupture probability model, which could potentially support such treatment decisions.

Methods

Segmented image data and patient information obtained from two patient cohorts including 203 patients with 249 aneurysms were used for patient-specific computational fluid dynamics simulations and subsequent evaluation of the statistical model in terms of accuracy, discrimination, and goodness of fit. The model's performance was further compared to a similarity-based approach for rupture assessment by

SUBMITTER: Detmer FJ 

PROVIDER: S-EPMC6290995 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature