Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8⁺ T Cell-Effector Responses.

ABSTRACT: T-cell priming occurs when a naïve T cell recognizes cognate peptide-MHC complexes on an activated antigen-presenting cell. The circumstances of this initial priming have ramifications on the fate of the newly primed T cell. Newly primed CD8⁺ T cells can embark onto different trajectories, with some becoming short-lived effector cells and others adopting a tissue resident or memory cell fate. To determine whether T-cell priming influences the quality of the effector T-cell response to tumors, we used transnuclear CD8⁺ T cells that recognize the melanoma antigen TRP1 using TRP1^high or TRP1^low TCRs that differ in both affinity and fine specificity. From a series of altered peptide ligands, we identified a point mutation (K8) in a nonanchor residue

SUBMITTER: Clancy-Thompson E 

PROVIDER: S-EPMC6290996 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature