Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation.

ABSTRACT:

Background & aims

Glycogen synthase kinase 3β (Gsk3β [Gsk3b]) is a ubiquitously expressed kinase with distinctive functions in different types of cells. Although its roles in regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have been well documented, the underlying mechanisms remain ambiguous, in part because of the lack of cell-specific tools in vivo.

Methods

We created a myeloid-specific Gsk3b knockout (KO) strain to study the function of Gsk3β in macrophages in a murine liver partial warm ischaemia model.

Results

Compared with controls, myeloid Gsk3b KO mice were protected from IRI, with diminished proinflammatory but enhanced anti-inflammatory immune responses in livers. In bone marrow-derived macrophages, Gsk3β deficiency resulted

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6291010 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature