Danger signals activate a putative innate immune system during regeneration in a filamentous fungus.

ABSTRACT: The ability to respond to injury is a biological process shared by organisms of different kingdoms that can even result in complete regeneration of a part or structure that was lost. Due to their immobility, multicellular fungi are prey to various predators and are therefore constantly exposed to mechanical damage. Nevertheless, our current knowledge of how fungi respond to injury is scarce. Here we show that activation of injury responses and hyphal regeneration in the filamentous fungus Trichoderma atroviride relies on the detection of two danger or alarm signals. As an early response to injury, we detected a transient increase in cytosolic free calcium ([Ca2+]c) that was promoted by extracellular ATP, and which is likely regulated by a mechanism of calcium-induced calcium-release. In ad

SUBMITTER: Medina-Castellanos E 

PROVIDER: S-EPMC6291166 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature